Mixed Connective Tissue Disease Associated with MPO-ANCA-positive Polyangiitis

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ANCA associated glomerulonephritis in a patient with mixed connective tissue disease.

OBJECTIVE To investigate the diagnosis and treatment of mixed connective tissue disease (MCTD) and myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) associated vasculitis, which is a rare clinical entity in medical practice. METHODS A 35-year-old female of Asian origin was admitted to our hospital due to complaints of Raynaud's phenomenon, myalgia, arthralgia and fatigue. The pat...

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Pulmonary-Limited Granulomatosis with Polyangiitis Coexisting with Mixed Connective Tissue Disease.

Granulomatosis with polyangiitis (GPA) is a systemic disease characterized by necrotizing, granulomatous vasculitis of the upper and lower respiratory tracts and glomerulonephritis, and is classified as a classical or limited form. The classical form of GPA demonstrates the involvement of the upper respiratory tract, sinuses, lungs and kidneys, whereas the limited form is characterized by the l...

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[Mixed connective tissue disease].

Mixed connective tissue disease deserves to be a distinct disease entity due to the persistent citation of this disease in the literature since the original description by Sharp in 1972, in spite of the presence of several criticisms against the independency of this disease. The characteristic features of mixed connective tissue disease are: 1) the presence of anti-U1snRNP antibody with high ti...

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Mixed connective tissue disease with associated glomerulonephritis and hypocomplementaemia.

Mixed connective tissue disease is an increasingly recognized entity in which renal disease is thought to be unusual and associated hypocomplementaemia even more uncommon. A patient is described who had both these features and who also illustrates many of the characteristic features of this syndrome. The response to steroids of the systemic sclerosis component is well shown and an additional fe...

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Minimal-change nephrotic syndrome associated with mixed connective-tissue disease.

Sir, Mixed connective-tissue disease (MCTD) is a rheumato-logical disorder which has combined features of systemic lupus erythematosus, systemic sclerosis (SSc), polymyositisu dermatomyositis, and rheumatoid arthritis (RA) with anti-bodies to U 1 small nuclear ribonucleoprotein (U 1 snRNP). Although renal involvement was considered to be rare in the initial description w1x, several studies demo...

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ژورنال

عنوان ژورنال: Internal Medicine

سال: 2006

ISSN: 0918-2918,1349-7235

DOI: 10.2169/internalmedicine.45.1703